Endocrine physiology has been investigated in in vivo and in vitro experimental models involving from the most classical methodological to the most recent molecular and genomic approaches. Research includes: 1. metabolic and hormonal control of glycemic homeostasis, addressing both insulin secretion (in pancreatic islets and cell cultures) and insulin action (in target tissues and cells); 2. pathophysiological mechanisms of diabetes mellitus and its complications in several territories of the organism; 3. mechanisms related to secretion and action of thyroid hormone, growth hormone, melatonin, adrenal and gonadal steroids, among other hormones; 4. metabolic-hormonal interactions with the immune system and the inflammatory response. Researchers: Angelo Rafael Carpinelli, Carla Roberta de Oliveira Carvalho, Fábio Bessa Lima, José Cipolla Neto. Maria Tereza Nunes, Silvana Auxiliadora Bordin da Silva, Ubiratan Fabres Machado and William T. Festuccia